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M94A2324.TXT
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1994-10-25
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Document 2324
DOCN M94A2324
TI Probability of male-to-female HIV transmission among married couples in
Chiang Mai, Thailand.
DT 9412
AU Duerr A; Xia Z; Nagachinta T; Tovanabutra S; Tansuhaj A; Nelson K;
Centers for Disease Control, Atlanta.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):33 (abstract no. 105C). Unique
Identifier : AIDSLINE ICA10/94370251
AB OBJECTIVE: To investigate the dynamics of heterosexual HIV transmission
after repeated exposure to a single HIV+ partner in northern Thailand.
METHODS: HIV-positive (HIV+) male blood donors and their regular female
sex partners were interviewed separately about sexual practice (type &
frequency of intercourse), contraceptive use and sexually transmitted
disease (STD). Assessment included physical examination, STD cultures &
serologies, HIV (ELISA, WB & subtyping), and CD4 count. Women with HIV
risk factors other than sexual exposure to an index male were excluded.
RESULTS: Between 3/92 and 11/93 250 HIV+ men and their wives (or regular
girlfriends) were enrolled. 108 (43%) women were HIV+. In a subsample of
34 newly-married couples, the total number of at-risk sex acts could be
calculated as it was determined that the male was HIV+ prior to sexual
contact with the wife. 9/34 (26%) women were HIV+; the probability of
HIV transmission was 1.6 [0.6-2.6] per 1000 sexual contacts (vaginal).
All HIV isolates were subtype (clade) E. Transmission was more likely
when the wife gave a history of an STD (OR = 19.2, p = .01) or the CD4
count of the male was < 200 (OR = 4.5, p = .14). Very little condom use
was reported; no effect of anal intercourse, sex during menstruation,
+STD culture or oral contraceptive use was seen. CONCLUSION: The
probability of heterosexual HIV (subtype E) transmission in Thai
couples, while much lower than recent estimates of transmission from
Thai prostitutes, does not differ significantly from that seen among
European and American couples. Models of the effect of repeated sexual
exposure will be presented.
DE Adult *Blood Donors Contraceptive Devices/UTILIZATION Female Human
HIV Seropositivity/PSYCHOLOGY/*TRANSMISSION Male Risk Factors Sex
Behavior *Sexual Partners Sexually Transmitted Diseases/COMPLICATIONS
Thailand MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).